At least seven people were killed and multiple others injured when a UPS cargo plane crashed shortly after takeoff from Louisville International Airport in Kentucky on Tuesday evening, resulting in a massive fire and prompting a large-scale emergency response.
The incident occurred at approximately 5:15 p.m. local time on November 4, 2025, as the wide-body MD-11F aircraft departed from the airport. It crashed about three miles south of the airfield, near the intersection of Fern Valley and Grade Lane, and erupted into a fireball due to the significant amount of fuel it was carrying for its planned flight to Hawaii. Videos and eyewitness accounts showed thick plumes of black smoke rising into the sky, with the explosion engulfing nearby businesses.
Kentucky Governor Andy Beshear confirmed at least seven fatalities, with the death toll expected to rise as search efforts continue. At least 11 people sustained injuries, some described as “very significant,” and officials noted that individuals on the ground were among the casualties. Two employees from a nearby auto parts business remained unaccounted for, raising concerns about additional victims.
More than 100 firefighters responded to the scene, battling intense flames fueled by an estimated 38,000 gallons of jet fuel. Louisville Fire Chief Brian O’Neill reported that the fire was nearly contained by late Tuesday, but hot spots persisted, complicating rescue operations. A shelter-in-place order was initially issued for a five-mile radius and later reduced to one mile due to air quality concerns.
The Federal Aviation Administration (FAA) confirmed the crash of UPS Flight 2976 and stated that the National Transportation Safety Board (NTSB) would lead the investigation. A team of 28 NTSB investigators is scheduled to arrive on Wednesday to examine the wreckage and determine the cause. Preliminary data indicated the plane briefly climbed to 175 feet before descending, but officials emphasized it is too early to speculate on the cause.
The aircraft involved was a McDonnell Douglas MD-11, first manufactured in 1991 and converted to cargo use by UPS in 2006. It was carrying no hazardous materials that would pose environmental risks. UPS, which operates its global air hub, Worldport, in Louisville, has suspended package sorting operations there and expressed deep sorrow over the incident.
The crash has profoundly impacted the Louisville community, where UPS is a major employer with thousands of workers. Local leaders described the event as a devastating tragedy and praised the efforts of first responders. All public schools in Jefferson County will be closed on Wednesday as a precaution, and the airport is expected to reopen after temporary closures.
As the investigation proceeds, authorities warned that the crash site will remain active for several days, with ongoing risks from flammable materials. UPS and Boeing have pledged support for the probe. The incident highlights the challenges of aging aircraft fleets, as UPS and FedEx plan to retire MD-11s in the coming years.