Comedian Rosie O’Donnell has revealed dramatic weight loss through diabetes medication Mounjaro, expressing shock at her new size-12 physique while preparing for an Australian tour. The media personality credits the drug and lifestyle changes for her transformation amid a relocation to Ireland following Donald Trump’s re-election.
Rosie O’Donnell, the 63-year-old actress and talk show host, publicly showcased her significant body transformation in an Instagram post showing her in form-fitting athleisure wear. She explicitly attributed the change to Mounjaro, a type-2 diabetes medication known for weight-loss side effects, calling it a “lifesaver” that helped her drop from an extra-large to size 12.
The revelation came on Wednesday, August 13, 2025, as O’Donnell shopped for comfortable clothing before her upcoming 22-hour flight to Australia. She currently resides in Ireland after leaving the United States in January 2025, having moved to her father’s homeland with her son Clay following Donald Trump’s presidential re-election.
O’Donnell began using Mounjaro in January 2023 under medical supervision, initially losing approximately 4 kilograms. She noted additional contributing factors included no longer employing a personal chef, forcing her to cook healthier meals for herself and her son. The star emphasized psychological adjustment challenges, admitting she remains “shocked” and “can’t see myself in this new, smaller body.”
Celebrity peers including actor Brad Garrett and singer Jann Arden immediately praised her transformation in social media comments, with fans noting improved health and confidence. The weight loss represents both a physical change and emotional milestone for O’Donnell, who described fleeing the U.S. as “heartbroken” over political divisions stemming from her longstanding feud with Trump.
The transformation coincides with O’Donnell’s upcoming Australian tour where she’ll perform her one-woman show “Common Knowledge” at Sydney’s Opera House in October. Her journey spotlights Hollywood’s growing trend of pharmaceutical weight management, with Mounjaro joining Ozempic as popular medical alternatives to traditional dieting.
Looking forward, O’Donnell will reflect on her relocation and health journey during her Australian performances while continuing to adjust to her new physique. Her story highlights complex intersections of celebrity culture, medical weight solutions, and political displacement in contemporary America.