Comedian and actress Amy Schumer showcased her significant weight loss, attributed to the drug Mounjaro, while attending a New York City event in a striking red Valentino dress on Tuesday, October 29, 2025. The comedian’s slimmed-down figure and confident appearance highlighted her ongoing transformation and openness about her GLP-1 journey, drawing widespread attention from fans and media alike.
Schumer was photographed during a stroll in Manhattan, wearing a romantic red mini dress from Valentino that featured a scoop neck, buttons down the front, and a centered bow accent. She paired the thigh-grazing number with pointy-toe black pumps from the same fashion house, completing her look with straightened blonde hair and minimal accessories. The outing was part of her attendance at an event for music producer Mark Ronson’s newly released memoir, “Night People: How to Be a DJ in ’90s New York City,” where she mingled with other celebrities and shared moments on social media.
Later that evening, Schumer posted images from the event on Instagram, taken by celebrity photographer Elder Ordonez, whom she described as “always so friendly.” In the caption, she credited her makeup artist Mariel Barrera and hairstylist Jae Manuel Cardenas for her glamorous appearance. The post garnered praise from fellow stars, including Chelsea Handler, who commented, “Looking like a real buttercup!” and Nicky Hilton, who called her “gorgeous,” reflecting the positive reception from her industry peers.
This public display is a continuation of Schumer’s weight loss journey, which she has been documenting openly. In March 2025, she revealed on social media that she had been using Mounjaro, a GLP-1 receptor agonist, after a previous attempt with Wegovy resulted in a “terrible experience” marked by vomiting and discomfort. She emphasized that Mounjaro has been more effective and tolerable, contributing to her loss of at least 40 pounds and improvements in her overall well-being, such as fuller hair, better skin, and increased energy.
Schumer’s transformation began gaining attention earlier when she discussed losing 30 pounds on the “Howard Stern Show” in 2024, initially crediting Ozempic before clarifying her use of Wegovy. Since switching to Mounjaro, she has frequently shared updates, including a recent mirror selfie that displayed her flat abs with the caption “no filter no filler no clean mirror,” underscoring her commitment to authenticity. Her journey reflects a broader shift in how celebrities address weight loss, moving away from secrecy toward transparency.
Advocating for honesty, Schumer has criticized other public figures for hiding their use of semaglutide-based drugs. In a 2023 appearance on “Watch What Happens Live,” she urged stars to “just stop” denying their interventions and “be real with the people,” positioning herself as a voice for accountability in an industry often scrutinized for unrealistic beauty standards. This stance aligns with her comedic persona, which often tackles personal and societal issues with humor and candor.
The implications of Schumer’s openness extend beyond celebrity culture, potentially influencing public attitudes toward weight management and pharmaceutical aids. As GLP-1 drugs like Mounjaro gain popularity for their efficacy, her experience highlights both the benefits and challenges, such as side effects and cost, that users may face. By sharing her story, she helps normalize conversations about body image and health, encouraging others to make informed decisions without shame.
Looking forward, Schumer’s continued visibility and advocacy may further destigmatize weight loss discussions and promote a more inclusive view of health. Her ability to blend personal transformation with public commentary sets a precedent for how figures in entertainment can impact social issues, suggesting that her influence will persist as she navigates future projects and personal milestones.